Children with trisomy 21 are a group at risk for severe COVID-19: Case reports from a COVID-19 treatment unit in Addis Ababa, Ethiopia

Children with trisomy 21 are a group at risk for severe COVID-19: Case reports from a COVID-19 treatment unit in Addis Ababa, Ethiopia

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Trisomy 21 (Down syndrome) is a chromosomal disorder associated with humoral and cellular immunologic impairments among other systemic manifestations.It occurs at a frequency of 1 in 750 live births.There are increasing reports of children with Down click here syndrome presenting signs of severe COVID-19.The literature from Africa on pediatric COVID-19 and risk stratification for severe disease is scant.A summary of the clinical features, complications, and treatment outcomes of three Ethiopian children with Trisomy 21 and severe COVID-19 along with a discussion nacrack.com of the correlation between trisomy 21 immunology and severe SARS CoV-2 infection is presented.